Predicting adverse side effects of drugs

An Algorithmic Framework for Predicting Side-Effects of Drugs

One of the critical stages in drug development is the identification of potential side effects for promising drug leads. Large-scale clinical experiments aimed at discovering such side effects are very costly and may miss subtle or rare side effects. Previous attempts to systematically predict side effects are sparse and consider each side effect independently. In this work, we report on a nove...

Side effects of drugs.

Matthews, H, British Medical_Journal, 1971, 1, 519. 2 Medd, R K, Archives of Toxicology, 1973, 31, 163. 3 Yatzidis, H, et al, Lancet, 1965, 2, 216. 4 Hagstam, K E, Larsson, L-E, and Thysell, H, Acta Medica Scandinavica, 1966, 180, 593. 5 Vale, J A, et al, British MedicalyJournal, 1975, 1, 5. 6 Rosenbaum, J L, Ronquillo, E, and Argyres, S N,J_ournal of theJr. Albert Einstein Medical Center, 1968...

Side Effects of Drugs

[Side-effects of drugs].

other epidemiological characteristics and both lived in an area where hepatitis A is highly endemic. The low prevalence of anti-HAV in patients with thalassaemia is unlikely to be due to a resistance to the infection endowed by the disease, since an increased prevalence of anti-HBs as well as of antibodies to cytomegalovirus and other viruses has been found in such children." Thus regular blood...

[Side effects of drugs].

A 55-year-old Caucasian man with a history of thyrotoxicosis treated with carbimazole was admitted to hospital in January 1976 with epigastric pain and weight loss. Laparotomy disclosed an antral carcinoma of the stomach with extensive lymph node disease, and local resection was carried out. Histological examination confirmed a well-differentiated adenocarcinoma with mestastases in lymph nodes....